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Garcinol is a polyisoprenylated benzophenone derivative from the rind of Garcinia indica fruit and is a potent inhibitor of histone acetyltransferases p300 and PCAF in-vitro. p300, also known as E1A binding protein p300, regulates cell growth and division through interacting with numerous transcription factors, and the p53 associated trancriptional coactivator PCAF (P300/CBP-associated factor) plays a direct role in transcriptional regulation.
Garcinol predominantly down-regulates global gene expression in HeLa cells. Additional research shows that Garcinol exhibits anti-carcinogenic and anti-inflammatory properties through selectively suppressing Prostaglandin E2 synthesis and 5-lipoxygenase product formation. It promotes neurogenesis in corticol progenitor cells and contributes for ex-vivo expansion of human hematopoietic stem cells (hHSC).
1. Nishino, T., et al. 2011. PLoS One. 6(9): e24298. PMID: 21931675
2. Weng, MS., et al. 2011. J Agric Food Chem. 59(3): 1031-1040. PMID: 21214247