In drug development, the term Trojan horse encompasses a variety of strategies to deliver drugs in a concealed, safe and efficient way to the target. The main objectives of this strategy are firstly to overcome barriers, such as the blood brain-barrier or simply the cell membrane, which shield the target (Troy) from a drug (the Greeks), secondly, to specifically attack the disease rather than the whole body and thirdly, to achieve a slow drug release over time with no sudden concentration peaks. This approach does not only sound awesome on a metaphoric level, but also makes use of some nifty biological tricks.
Exosomes are cell-secreted vesicles with a diameter between 30-150nm which contain producer cell-derived protein, lipid and nucleic acid cargoes. Exosomes complex structure, coated with various membrane-bound proteins, can permeate target cells, enabling direct cell-to-cell communication between neighbouring and distant cells. Now researchers are looking at the possibility of using exosomes derived from plants for therapeutic applications
Cell Guidance Systems Ltd, a specialist in exosome research reagents and services, today announced the launch of a new product for the purification of exosomes from blood and other samples. The Exo-spin™ 96 exosome purification kit allows researchers to purify exosome samples in the standard 96 well plate format.
The characterisation of exosomes via multiple, complimentary techniques is necessary as a basic step to understand the sample before any further analysis. Here we discuss how products and services from Cell Guidance Systems can help with this important task.