Growth factors are very potent molecules with short half-lives. Their fragility limits both their research and therapeutic potential. PODS® (Polyhedrin Delivery System) provides a highly effective crystalline formulation for essentially any protein which are slowly released as the crystal degrades. Numerous applications have been developed for PODS®.
PODS® is a sustained-release co-crystal depot formulation which continuously replenishes proteins from millions of local microscopic protein crystals which can be placed at a defined distance from cells. PODS® micro-depots release a steady stream of bioactive protein providing zero-order kinetics.
PODS® application areas
• Bioink functionalization • 3D culture including organoids • Functionalizing scaffolds • Microfluidics (lab on a chip) • Improved and simplified stem cell culture • In-vivo survival agent for implanted cells • Therapeutic protein delivery